摘要
T细胞的基因工程可导致增强的免疫介导的肿瘤破坏,并为肿瘤治疗提供巨大潜能。近期研究集中在采用病毒基因转移的方法针对肿瘤抗原设计重定向T细胞特异性的受体上。这项策略在临床试验第一阶段已取得巨大成功。然而,仍有需要克服的挑战。一方面,T细胞功能可被进一步改进来优化治疗结果。另一方面,需要所谓的安全开关来处理可能的开启和关闭靶标毒性。本文中,在详细讨论当前用来增强过继转输T细胞的效应功能、持久性和安全性的策略之前,我们将对T细胞基因治疗的成功和风险进行简短综述。
关键词: 过继免疫治疗,癌症,CAR,嵌合抗原受体,基因疗法,T细胞,T细胞受体,肿瘤免疫学。
Current Gene Therapy
Title:T Cell Tuning for Tumour Therapy: Enhancing Effector Function and Memory Potential of Therapeutic T cells
Volume: 15 Issue: 3
Author(s): Mathias H. Zech, Pedro Velica and Hans J. Stauss
Affiliation:
关键词: 过继免疫治疗,癌症,CAR,嵌合抗原受体,基因疗法,T细胞,T细胞受体,肿瘤免疫学。
摘要: The genetic engineering of T cells can lead to enhanced immune-mediated tumour destruction and harbors a great potential for the treatment of cancer. Recent efforts have centered on the design of receptors to re-direct the specificity of T cells towards tumour antigens by means of viral gene transfer. This strategy has shown great success in a number of phase one clinical trials. However, there are still challenges to overcome. On the one hand, T cell function can be further improved to optimize the therapeutic outcome. On the other hand, so called safety switches are required to deal with possible on and off target toxicities. In this review, we will give a brief summary of the success and risks of T cell gene therapy before discussing in detail current strategies to enhance effector function, persistence and safety of adoptively transferred T cells.
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Mathias H. Zech, Pedro Velica and Hans J. Stauss , T Cell Tuning for Tumour Therapy: Enhancing Effector Function and Memory Potential of Therapeutic T cells, Current Gene Therapy 2015; 15 (3) . https://dx.doi.org/10.2174/1566523215666150126123037
DOI https://dx.doi.org/10.2174/1566523215666150126123037 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
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