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CNS & Neurological Disorders - Drug Targets


ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

Commentary: The Effects of Psychological Stress on Microglial Cells in the Brain

Author(s): Ti-Fei Yuan, Gonglin Hou, Ying Zhao and Oscar Arias-Carrion

Volume 14, Issue 3, 2015

Page: [304 - 308] Pages: 5

DOI: 10.2174/1871527314666150123122851


Psychological stress leads to activation and proliferation of microglial cells in different brain regions. These effects are mediated by inflammatory cytokines, as well as stress hormones including glucocorticoids and norepinephrine. Eliminating microglia from the nervous system or blocking their activation prevented the stress-induced impairments on brain cognitive functions. We conclude that microglial cells are important meditators underlying anti-depression therapies.

Keywords: Antidepressant, glucocorticoid, microglia, norepinephrine, stress.

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