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Current Organocatalysis


ISSN (Print): 2213-3372
ISSN (Online): 2213-3380

Construction of a Soluble Supramolecular Glutathione Peroxidase Mimic based on Host-Guest Interaction

Author(s): Yanzhen Yin, Shufei Jiao, Ruirui Zhang, Xueqian Wang, Li Zhang and Lan Yang

Volume 2 , Issue 1 , 2015

Page: [64 - 70] Pages: 7

DOI: 10.2174/2213337202666150121230931

Price: $65


A soluble glutathione peroxidase mimic with the optimum structure (NCD-Te-NCD2.2) was constructed based on the supramolecular host-guest interaction. The self-assembled structure and catalytic mechanism of NCD-Te-NCD2.2 were detailed investigation. It was proved that NCD-Te-NCD2.2 could form the hollow vesicle-like aggregates in water. And saturation kinetics measurement indicated that NCD-Te- NCD2.2 exhibited the typical enzyme catalytic behavior. Furthermore, benefited from the hydrophobic microenvironment in vesicle-like aggregates, NCD-Te-NCD2.2 exhibited the specific recognition ability for hydrophobic substrates, which was one of the important characteristics of native glutathione peroxidase. The successful construction of NCD-Te-NCD2.2 not only provides an efficient preparation method for soluble GPx mimic but also highlights for construction of other giant supramolecular biomimetic enzymes.

Keywords: Biomimetics, enzyme activity, glutathione peroxidase, supramolecular, host-guest interaction.

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