Abstract
Traumatic Spinal Cord Injuries (TSCI), due to their devastating nature, present several interventional challenges (extensive inflammation, axonal tethering, scar formation, neuronal degeneration and functional loss) that need to be addressed before even a slight neuronal recovery can be achieved. Recent post-TSCI investigational approaches include a combination of “support and therapeutic” strategies capable of providing localized delivery of therapeutic molecules along with specialized architecture to allow axonal growth and conformal repair. This review provides a brief overview of multifunctional therapeutic delivery strategies for effective neuroregeneration post-TSCI with special emphasis on intrathecal hydrogel-based injectable systems, chondroitinase ABC releasing matrices, micro/nano-sized particulate strategies, 3D-scaffold architectures, biopolymeric channeled bridges for directed neuronal growth, functionalized nerve conduits, nano- and micro-fibrous scaffolds and multicomponent combinatorial paradigms for localized delivery to spinal cord. In addition; a comprehensive account of most widely employed macromolecules and the related neuro-pharmacological, -anatomical, and -functionaloutcomes conferred by the abovementioned neural tissue engineering approaches is provided. Furthermore, the performance of individual delivery systems towards the enhancement of effectiveness, efficiency, and stability of therapeutic molecules and neurotrophic factors is discussed. In conclusion, it is suggested that a multifunctional combinatorial device assimilating the biomaterial, cellular, molecular, structural and functional aspects altogether is the best way forward for effective neuroregeneration post-TSCI.
Keywords: Spinal cord injury, hydrogels, scaffolds, multiple channel bridges, nerve conduits, fibrous architectures, neurotrophic factors, sustained release.
Current Pharmaceutical Design
Title:Multifunctional Therapeutic Delivery Strategies for Effective Neuro-Regeneration Following Traumatic Spinal Cord Injury
Volume: 21 Issue: 12
Author(s): Pradeep Kumar, Yahya E. Choonara, Girish Modi, Dinesh Naidoo and Viness Pillay
Affiliation:
Keywords: Spinal cord injury, hydrogels, scaffolds, multiple channel bridges, nerve conduits, fibrous architectures, neurotrophic factors, sustained release.
Abstract: Traumatic Spinal Cord Injuries (TSCI), due to their devastating nature, present several interventional challenges (extensive inflammation, axonal tethering, scar formation, neuronal degeneration and functional loss) that need to be addressed before even a slight neuronal recovery can be achieved. Recent post-TSCI investigational approaches include a combination of “support and therapeutic” strategies capable of providing localized delivery of therapeutic molecules along with specialized architecture to allow axonal growth and conformal repair. This review provides a brief overview of multifunctional therapeutic delivery strategies for effective neuroregeneration post-TSCI with special emphasis on intrathecal hydrogel-based injectable systems, chondroitinase ABC releasing matrices, micro/nano-sized particulate strategies, 3D-scaffold architectures, biopolymeric channeled bridges for directed neuronal growth, functionalized nerve conduits, nano- and micro-fibrous scaffolds and multicomponent combinatorial paradigms for localized delivery to spinal cord. In addition; a comprehensive account of most widely employed macromolecules and the related neuro-pharmacological, -anatomical, and -functionaloutcomes conferred by the abovementioned neural tissue engineering approaches is provided. Furthermore, the performance of individual delivery systems towards the enhancement of effectiveness, efficiency, and stability of therapeutic molecules and neurotrophic factors is discussed. In conclusion, it is suggested that a multifunctional combinatorial device assimilating the biomaterial, cellular, molecular, structural and functional aspects altogether is the best way forward for effective neuroregeneration post-TSCI.
Export Options
About this article
Cite this article as:
Kumar Pradeep, Choonara E. Yahya, Modi Girish, Naidoo Dinesh and Pillay Viness, Multifunctional Therapeutic Delivery Strategies for Effective Neuro-Regeneration Following Traumatic Spinal Cord Injury, Current Pharmaceutical Design 2015; 21 (12) . https://dx.doi.org/10.2174/1381612821666150115152323
DOI https://dx.doi.org/10.2174/1381612821666150115152323 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Derivation of Clinically Applicable Schwann Cells from Bone Marrow Stromal Cells for Neural Repair and Regeneration
CNS & Neurological Disorders - Drug Targets Serotonin<sub>2c</sub> Receptor Constitutive Activity: In vivo Direct and Indirect Evidence and Functional Significance
Central Nervous System Agents in Medicinal Chemistry The Therapeutic Potential of Neural Stem Cells in Cerebral Ischemia
Current Signal Transduction Therapy Are Hsp90 Inhibitors Good Candidates Against Covid-19?
Current Protein & Peptide Science Pericyte: Potential Target for Hemorrhagic Stroke Prevention and Treatment
Current Drug Delivery Role of Free Radicals and Poly(ADP-Ribose)Polymerase-1 in the Development of Spinal Cord Injury: New Potential Therapeutic Targets
Current Medicinal Chemistry Opioids Resistance in Chronic Pain Management
Current Neuropharmacology Opioids and the Blood-Brain Barrier: A Dynamic Interaction with Consequences on Drug Disposition in Brain
Current Neuropharmacology Multiple Sclerosis and Neuroinflammation: The Overview of Current and Prospective Therapies
Current Pharmaceutical Design Clinical Assessment of Carotid Atherosclerosis Inflammation by Positron Emission Tomography
Current Molecular Medicine Application of Decoy Oligonucleotides as Novel Therapeutic Strategy: A Contemporary Overview
Current Drug Discovery Technologies Animal Peptides Targeting Voltage-Activated Sodium Channels
Current Pharmaceutical Design Neurological Disorders of Purine and Pyrimidine Metabolism
Current Topics in Medicinal Chemistry The Cholinergic Potential, the Vagus Nerve and Challenges in Treatment of Traumatic Brain Injury
Current Pharmaceutical Design Onconeural Versus Paraneoplastic Antigens?
Current Medicinal Chemistry Glutamate Transporter 1: Target for the Treatment of Alcohol Dependence
Current Medicinal Chemistry Neuroprotective Effects of Exercise Treatments After Injury: The Dual Role of Neurotrophic Factors
Current Neuropharmacology Engineered Magnetic Core-Shell Structures
Current Pharmaceutical Design Imaging Neuroinflammation in Ischemic Stroke and in the Atherosclerotic Vascular Disease
Current Vascular Pharmacology Tetramethylpyrazine Facilitates Functional Recovery after Spinal Cord Injury by Inhibiting MMP2, MMP9, and Vascular Endothelial Cell Apoptosis
Current Neurovascular Research