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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Neonatal Brain Hemorrhage (NBH) of Prematurity: Translational Mechanisms of the Vascular-Neural Network

Author(s): Tim Lekic, Damon Klebe, Roy Poblete, Paul R. Krafft, William B. Rolland, Jiping Tang and John H. Zhang

Volume 22, Issue 10, 2015

Page: [1214 - 1238] Pages: 25

DOI: 10.2174/0929867322666150114152421

Price: $65

Abstract

Neonatal brain hemorrhage (NBH) of prematurity is an unfortunate consequence of preterm birth. Complications result in shunt dependence and long-term structural changes such as posthemorrhagic hydrocephalus, periventricular leukomalacia, gliosis, and neurological dysfunction. Several animal models are available to study this condition, and many basic mechanisms, etiological factors, and outcome consequences, are becoming understood. NBH is an important clinical condition, of which treatment may potentially circumvent shunt complication, and improve functional recovery (cerebral palsy, and cognitive impairments). This review highlights key pathophysiological findings of the neonatal vascular-neural network in the context of molecular mechanisms targeting the posthemorrhagic hydrocephalus affecting this vulnerable infant population.

Keywords: Cerebral palsy, experimental, germinal matrix hemorrhage, hydrocephalus, mental retardation, neonatal rats, neurological dysfunction, pathogenesis, stroke.


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