Abstract
Selective targeting of ligand-targeted liposomes containing anticancer drugs or therapeutic genes to cell surface receptors expressed on cancer cells is a recognized strategy for improving the therapeutic effectiveness of conventional chemotherapeutics or gene therapeutics. Some recent advances in the field of ligand-targeted liposomes for the treatment of cancer are summarized including: selection criteria for the receptors to be targeted, choice of targeting ligands and choice of encapsulated therapeutics. Targeting of liposomes to solid tumors, versus angiogenic endothelial cells versus vascular targets is discussed. Ligand-targeted liposomes have shown considerable promise in preclinical xenograft models and are poised for clinical development.
Keywords: liposome, immunoliposome, ligand, antibody, cancer, gene therapy, targeted therapy
Current Drug Delivery
Title: Ligand-Targeted Liposomes for Cancer Treatment
Volume: 2 Issue: 4
Author(s): Puja Sapra, Pradeep Tyagi and Theresa M. Allen
Affiliation:
Keywords: liposome, immunoliposome, ligand, antibody, cancer, gene therapy, targeted therapy
Abstract: Selective targeting of ligand-targeted liposomes containing anticancer drugs or therapeutic genes to cell surface receptors expressed on cancer cells is a recognized strategy for improving the therapeutic effectiveness of conventional chemotherapeutics or gene therapeutics. Some recent advances in the field of ligand-targeted liposomes for the treatment of cancer are summarized including: selection criteria for the receptors to be targeted, choice of targeting ligands and choice of encapsulated therapeutics. Targeting of liposomes to solid tumors, versus angiogenic endothelial cells versus vascular targets is discussed. Ligand-targeted liposomes have shown considerable promise in preclinical xenograft models and are poised for clinical development.
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Cite this article as:
Sapra Puja, Tyagi Pradeep and Allen M. Theresa, Ligand-Targeted Liposomes for Cancer Treatment, Current Drug Delivery 2005; 2 (4) . https://dx.doi.org/10.2174/156720105774370159
DOI https://dx.doi.org/10.2174/156720105774370159 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
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