Abstract
The development of non-microbial methods for the selective functionalization of non-activated C-H bonds has constituted a challenge, with important economical and environmental implications, for chemists for over a century. The present review provides a comprehensive and current compendium that illustrates the power of C-H functionalization and, namely, of remote functionalization strategies, to expeditiously access vitamin D analogs with intricate structures.
Keywords: Analogs, calcitriol, Free radical, Non-activated carbons, Remote functionalization, Synthesis, Vitamin D.
Current Topics in Medicinal Chemistry
Title:Functionalization of Non-Activated C-H Bonds in the Synthesis of Vitamin D Metabolites and Analogs
Volume: 14 Issue: 21
Author(s): Edelmiro Moman
Affiliation:
Keywords: Analogs, calcitriol, Free radical, Non-activated carbons, Remote functionalization, Synthesis, Vitamin D.
Abstract: The development of non-microbial methods for the selective functionalization of non-activated C-H bonds has constituted a challenge, with important economical and environmental implications, for chemists for over a century. The present review provides a comprehensive and current compendium that illustrates the power of C-H functionalization and, namely, of remote functionalization strategies, to expeditiously access vitamin D analogs with intricate structures.
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Cite this article as:
Moman Edelmiro, Functionalization of Non-Activated C-H Bonds in the Synthesis of Vitamin D Metabolites and Analogs, Current Topics in Medicinal Chemistry 2014; 14 (21) . https://dx.doi.org/10.2174/1568026615666141208100811
DOI https://dx.doi.org/10.2174/1568026615666141208100811 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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