Functionalization of Non-Activated C-H Bonds in the Synthesis of Vitamin D Metabolites and Analogs

Title:Functionalization of Non-Activated C-H Bonds in the Synthesis of Vitamin D Metabolites and Analogs

Volume: 14 Issue: 21

Author(s): Edelmiro Moman

Affiliation:

• ProSciens, 2 - 4 rue du Palais de Justice, L-1841 Luxembourg, Luxembourg.,Luxembourg

Keywords: Analogs, calcitriol, Free radical, Non-activated carbons, Remote functionalization, Synthesis, Vitamin D.

Abstract: The development of non-microbial methods for the selective functionalization of non-activated C-H bonds has constituted a challenge, with important economical and environmental implications, for chemists for over a century. The present review provides a comprehensive and current compendium that illustrates the power of C-H functionalization and, namely, of remote functionalization strategies, to expeditiously access vitamin D analogs with intricate structures.

Cite this article as:

Moman Edelmiro, Functionalization of Non-Activated C-H Bonds in the Synthesis of Vitamin D Metabolites and Analogs, Current Topics in Medicinal Chemistry 2014; 14(21) . https://dx.doi.org/10.2174/1568026615666141208100811