Abstract
The Gemini analogs are the last significant contribution to the family of vitamin D derivatives in medicine, for the treatment of cancer. The first Gemini analog was characterized by two symmetric side chains at C-20. Following numerous modifications, the most active analog bears a C-23-triple bond, C-26, 27- hexafluoro substituents on one side chain and a terminal trideuteromethylhydroxy group on the other side chain. This progression was possible due to improvements in the synthetic methods for the preparation of these derivatives, which allowed for increasing molecular complexity and complete diastereoselective control at C-20 and the substituted sidechains.
Keywords: Chemical synthesis, Gemini analogs, Steroid, Vitamin D.
Current Topics in Medicinal Chemistry
Title:Gemini Analogs of Vitamin D
Volume: 14 Issue: 21
Author(s): Gonzalo Pazos, Marcos L. Rivadulla, Xenxo Perez-García, Zoila Gandara and Manuel Perez
Affiliation:
Keywords: Chemical synthesis, Gemini analogs, Steroid, Vitamin D.
Abstract: The Gemini analogs are the last significant contribution to the family of vitamin D derivatives in medicine, for the treatment of cancer. The first Gemini analog was characterized by two symmetric side chains at C-20. Following numerous modifications, the most active analog bears a C-23-triple bond, C-26, 27- hexafluoro substituents on one side chain and a terminal trideuteromethylhydroxy group on the other side chain. This progression was possible due to improvements in the synthetic methods for the preparation of these derivatives, which allowed for increasing molecular complexity and complete diastereoselective control at C-20 and the substituted sidechains.
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Cite this article as:
Pazos Gonzalo, Rivadulla L. Marcos, Perez-García Xenxo, Gandara Zoila and Perez Manuel, Gemini Analogs of Vitamin D, Current Topics in Medicinal Chemistry 2014; 14 (21) . https://dx.doi.org/10.2174/1568026615666141208100411
DOI https://dx.doi.org/10.2174/1568026615666141208100411 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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