摘要
生物医学成像是癌症等疾病诊断和治疗的一个重要工具。可能确实生物医学成像方法应用促进了医学的进一步发展。生物医学成像方法的灵敏度和分辨率可以通过造影剂提高。此外, 产生了一个理想化的想法:造影剂是否可以用作药物。因此,一剂既可以用于疾病的诊断也能用于疾病的治疗(即,治疗诊断)。这将简化医疗疾病的治疗,也将有利于患者。混合(Ln1xLn2yO3 x + y = 2)或纯(Ln2O3)氧化镧系(Ln)纳米颗粒(Ln = Eu、Gd、 Dy、Tb、 Ho和Er)是潜在的多模式成像剂和癌症治疗剂。镧系元素有各种磁性和光学特性,分别用于磁共振成像(MRI)和荧光成像(FI)。他们也发射非常细小的x射线,用于x射线计算机断层扫描(CT)。另外在稳定的放射性核素中,钆-157(157 gd)有着最高的热中子俘获截面,用于钆中子俘获治疗(GdNCT)。因此,混合或纯镧系元素氧化物纳米粒子(即可以用于多模式成像方法,例如MRI-CT MRI-FI CT-FI,MRICT - FI)和癌症治疗(即GdNCT)。因为混合或纯镧系元素氧化物纳米颗粒是单相和固态,它们可以很容易地合成,紧凑和稳固,这有益于其在生物医学上的应用。本文综述镧系元素的物理性质、合成、混合材料的特点、多模式成像、癌症治疗,并讨论了纯氧化镧纳米颗粒在癌症治疗的应用。
关键词: 癌症治疗,荧光成像-计算机断层扫描,钆中子俘获治疗,混合或纯镧系元素氧化物纳米颗粒,多模式成像,磁共振成像-计算机断层扫描,磁共振成像-计算机断层扫描-荧光成像,磁共振成像-荧光成像
Current Medicinal Chemistry
Title:Multi-Modal Imaging and Cancer Therapy Using Lanthanide Oxide Nanoparticles: Current Status and Perspectives
Volume: 22 Issue: 5
Author(s): J.Y. Park, Y. Chang and G.H. Lee
Affiliation:
关键词: 癌症治疗,荧光成像-计算机断层扫描,钆中子俘获治疗,混合或纯镧系元素氧化物纳米颗粒,多模式成像,磁共振成像-计算机断层扫描,磁共振成像-计算机断层扫描-荧光成像,磁共振成像-荧光成像
摘要: Biomedical imaging is an essential tool for diagnosis and therapy of diseases such as cancers. It is likely true that medicine has developed with biomedical imaging methods. Sensitivity and resolution of biomedical imaging methods can be improved with imaging agents. Furthermore, it will be ideal if imaging agents could be also used as therapeutic agents. Therefore, one dose can be used for both diagnosis and therapy of diseases (i.e., theragnosis). This will simplify medical treatment of diseases, and will be also a benefit to patients. Mixed (Ln1xLn2yO3, x + y = 2) or unmixed (Ln2O3) lanthanide (Ln) oxide nanoparticles (Ln = Eu, Gd, Dy, Tb, Ho, Er) are potential multi-modal imaging and cancer therapeutic agents. The lanthanides have a variety of magnetic and optical properties, useful for magnetic resonance imaging (MRI) and fluorescent imaging (FI), respectively. They also highly attenuate X-ray beam, useful for X-ray computed tomography (CT). In addition gadolinium-157 (157Gd) has the highest thermal neutron capture cross section among stable radionuclides, useful for gadolinium neutron capture therapy (GdNCT). Therefore, mixed or unmixed lanthanide oxide nanoparticles can be used for multi-modal imaging methods (i.e., MRI-FI, MRI-CT, CT-FI, and MRICT- FI) and cancer therapy (i.e., GdNCT). Since mixed or unmixed lanthanide oxide nanoparticles are single-phase and solid-state, they can be easily synthesized, and are compact and robust, which will be beneficial to biomedical applications. In this review physical properties of the lanthanides, synthesis, characterizations, multi-modal imagings, and cancer therapy of mixed and unmixed lanthanide oxide nanoparticles are discussed.
Export Options
About this article
Cite this article as:
J.Y. Park, Y. Chang and G.H. Lee , Multi-Modal Imaging and Cancer Therapy Using Lanthanide Oxide Nanoparticles: Current Status and Perspectives, Current Medicinal Chemistry 2015; 22 (5) . https://dx.doi.org/10.2174/0929867322666141128162843
DOI https://dx.doi.org/10.2174/0929867322666141128162843 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Solving the Blood-Brain Barrier Challenge for the Effective Treatment of HIV Replication in the Central Nervous System
Current Pharmaceutical Design Endocannabinoid System in Neurological Disorders
Recent Patents on CNS Drug Discovery (Discontinued) Anticancer Potential of Dietary Natural Products: A Comprehensive Review
Anti-Cancer Agents in Medicinal Chemistry 2D, 3D, G-QSAR and Docking Studies of Thiazolyl-pyrazoline Analogues as Potent (Epidermal Growth Factor Receptor-tyrosine Kinase) EGFR-TK Inhibitors
Letters in Drug Design & Discovery Taming Oncogenic Signaling at Protein Interfaces: Challenges and Opportunities
Current Topics in Medicinal Chemistry Angiopoietin-2 Axis Inhibitors: Current Status and Future Considerations for Cancer Therapy
Current Angiogenesis (Discontinued) NSAIDs and Chemoprevention
Current Cancer Drug Targets Farnesyltransferase Inhibitors: A Comprehensive Review Based on Quantitative Structural Analysis
Current Medicinal Chemistry Glioma Stem Cell Maintenance: The Role of the Microenvironment
Current Pharmaceutical Design Critical Roles of EGFR Family Members in Breast Cancer and Breast Cancer Stem Cells: Targets for Therapy
Current Pharmaceutical Design Emerging Therapies in the Treatment of Locally Advanced Squamous Cell Cancers of Head and Neck
Recent Patents on Anti-Cancer Drug Discovery Cyclophilin A as a Target of Cisplatin Chemosensitizers
Current Cancer Drug Targets Nanotechology-Based Strategies to Enhance the Efficacy of Photodynamic Therapy for Cancers
Current Drug Metabolism Design of Magnetic Nanoparticles-Assisted Drug Delivery System
Current Pharmaceutical Design Bevacizumab for Malignant Brain Gliomas. Which is the Current Evidence?
Recent Patents on Inflammation & Allergy Drug Discovery STAT3 as a Central Regulator of Tumor Metastases
Current Molecular Medicine Prognostic Role of Hedgehog-GLI1 Signaling Pathway in Aggressive and Metastatic Breast Cancers
Current Drug Metabolism Gold and Silver Nanoparticles for Applications in Theranostics
Current Topics in Medicinal Chemistry Importance of ABC Transporters in Drug Development
Current Pharmaceutical Design Small Molecules Targeting Mutant P53: A Promising Approach for Cancer Treatment
Current Medicinal Chemistry