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Anti-Cancer Agents in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

Recent Advances of Natural and Synthetic β-Carbolines as Anticancer Agents

Author(s): Mingming Zhang and Dianqing Sun

Volume 15 , Issue 5 , 2015

Page: [537 - 547] Pages: 11

DOI: 10.2174/1871520614666141128121812

Price: $65

Abstract

Cancer is a leading cause of mortality worldwide, being responsible for millions of deaths annually. Therefore, novel cancer chemotherapeutic agents are urgently needed to combat this devastating disease. β - Carboline alkaloids are an important class of natural products and medicinal molecules, which exert their anticancer activities through diverse mechanisms. In this review, we cover recent natural and synthetic β - carbolines with anticancer activity that have been reported in the literature (2010-July 2014), focusing on their chemical structures, anticancer properties, structure-activity relationships, and mechanisms of action.

Keywords: Alkaloid, Anticancer, Antitumor, β -Carboline, Mechanism of action, Natural product, Structureactivity relationship.

Graphical Abstract

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