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Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Synthesis and Antitubercular Screening of Some Novel 4H-1,4- Benzothiazines and their Sulfones Under Environment Benign Solvent Free Conditions as Future Anti-Tubercular Agents

Author(s): Anjali Guleria, Dinesh K. Jangid, Naveen Gautam, Richa Lakhotia, Abhay Chowdhary and Dinesh C. Gautam

Volume 18 , Issue 1 , 2015

Page: [48 - 52] Pages: 5

DOI: 10.2174/1386207317666141126164147

Price: $65

Abstract

Some novel analogs of 4H-1,4-benzothiazines were synthesized under environmentally benign solvent free conditions by one pot oxidative cyclocondensation of substituted 2- aminobenzenthiols with compounds having active methylene group and then converted in to sulfones. These compounds were examined as antitubercular agents against Mycobacterium tuberculosis H37Rv using REMA plate method. The best results have MICs from 6.4 to 8.8 μg/mL, comparable to phenothiazines. IR, NMR and mass spectral investigations are included for structural elucidation.

Keywords: 4H-1, 4-benzothiazines, antitubercular agents, green chemistry, REMA, sulfones.


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