摘要
CD44的表达以干性-相关特性(癌症启动细胞或癌症干细胞-CSC)标记细胞。这种细胞质域的膜糖蛋白直接与细胞骨架有关,在肿瘤发生中起至关重要的作用。CD44受体使细胞对肿瘤微环境产生应答变化,促进几种在远宿主组织中与肿瘤开始、发展和固定相关的信号事件。尽管在基因调控中跨膜蛋白的作用仍不清楚,但其在腺癌中的过度表达,主要由微RNA (miR)介导的靶标mRNA支持,是被广泛接受的。在此,我们收集的证据表明CD44是恶性肿瘤细胞最主要的标志之一,其可以在与肿瘤进展相关的不同表型中被发现。另外,CD44肿瘤受体在转录水平上有不同作用。因此,创新的治疗策略应该严重依赖其转移-促进能力。另外,选择性靶向细胞亚群体的概念可用于开发特定的治疗和/或诊断系统。基于靶向CD44+细胞的方法或许可提供一种策略来设计导向-治疗系统从而对抗包括假定CSC在内的多种恶性肿瘤细胞。
关键词: 癌症干细胞,CD44,上皮-间叶细胞转型,转移,肿瘤发展。
Current Cancer Drug Targets
Title:Looking out for Cancer Stem Cells’ Properties: The Value-Driving Role of CD44 for Personalized Medicines
Volume: 14 Issue: 9
Author(s): Sara Horta, Ana Lucia Agostinho, Rita Mateus, Lucilia Pereira, Carolina Pereira, Liliana Capinha, Slavomira Doktorovova, Alexandra Brito and Mafalda Videira
Affiliation:
关键词: 癌症干细胞,CD44,上皮-间叶细胞转型,转移,肿瘤发展。
摘要: The expression of CD44 tags cells with stemness-associated properties (cancer initiating cells or cancer stem cells - CSC). This membrane glycoprotein with a cytoplasmic domain indirectly associated with the cellular cytoskeleton, has a crucial role in tumorigenesis. The CD44 receptor enables the cell to respond to changes in tumor microenvironment, promoting several signaling events related to tumor initiation, progression and fixation in distant host tissues. Although the contribution of this transmembrane protein in gene regulation remains unclear, its overexpression in adenocarcinomas, mostly supported by microRNA (miR)-mediated upregulation of target mRNA, is widely accepted. Herein, we gather the evidence that CD44 is one of the most predominant markers of malignant cells and may be found in diverse phenotypes associated with tumor progression. Additionally, CD44 tumor receptors were found to have different roles at a transcriptional level. Thus, innovative therapeutic strategies should rely heavily on its metastasis-promoting ability. Furthermore, the concept of selectively targeting cell sub-populations may be used to develop specific therapeutic and/or diagnostic systems. An approach based on targeting CD44+ cells might provide a strategy to design guided-therapeutic systems against multiple malignant cells including putative CSC.
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Cite this article as:
Sara Horta , Ana Lucia Agostinho , Rita Mateus , Lucilia Pereira , Carolina Pereira , Liliana Capinha , Slavomira Doktorovova , Alexandra Brito and Mafalda Videira , Looking out for Cancer Stem Cells’ Properties: The Value-Driving Role of CD44 for Personalized Medicines, Current Cancer Drug Targets 2014; 14 (9) . https://dx.doi.org/10.2174/1568009614666141111154713
DOI https://dx.doi.org/10.2174/1568009614666141111154713 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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