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Current Organocatalysis


ISSN (Print): 2213-3372
ISSN (Online): 2213-3380

L-Arginine Catalysed Knoevenagel Condensation: An Unambiguous Synthesis of Cyano-Nitrophenylacetamide, Benzimidazole Acetonitrile & 3-Indole Substituted Alkenes

Author(s): K. Srinivas, Naresh Kumar Katari, P. Satya Karuna and M.S. Surendra Babu

Volume 2 , Issue 1 , 2015

Page: [44 - 50] Pages: 7

DOI: 10.2174/2213337201666141110222400

Price: $65


L-Arginine catalyzed Knoevenagel condensation of active methylene compounds, 2-cyano-N-(2- nitrophenyl)acetamide, 2-cyanomethyl benzimidazole, ethylcyanoacetate with benzaldehydes, indole-3- carboxaldehydes under mild and efficient conditions resulting in the formation of respective products. The isolation procedure is quiet easy and products recovered without further purification.

Keywords: 2-cyanomethyl benzimidazole, ethylcyanoacetate, indole-3-carboxaldehydes, knoevenagel reaction, L-arginine, Onitroaniline.

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