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Current Bioactive Compounds


ISSN (Print): 1573-4072
ISSN (Online): 1875-6646

Dietary Polyphenols for Prostate Cancer Therapy

Author(s): Yan A. Ivanenkov, Nina V. Chufarova, Mark S. Veselov and Alexander G. Majouga

Volume 10 , Issue 2 , 2014

Page: [76 - 111] Pages: 36

DOI: 10.2174/157340721002141001102524

Price: $65


This review describes the potential of a variety of physiologically active natural dietary polyphenols (PPhs) and their analogues, including derivatives of flavonoids, stilbenes, lignans, curcuminoids, and tannins, for prostate cancer chemotherapy. The large number of scientific papers on PPhs published during the last decade, particularly those focused on their therapeutic potential against prostate cancer cell lines, indicates rising interest in this group of compounds. Several polyphenolic agents are currently being investigated in advanced clinical trials as prominent cancer drug candidates while hundreds of related compounds are being evaluated in early clinical and preclinical studies. The review also covers the key mechanisms of antitumor action of natural PPhs against cancer cells.

Keywords: Chemotherapy, flavonoids, lignans, oncology, polyphenols, prostate cancer, stilbenes, tannins.

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