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Pharmaceutical Nanotechnology


ISSN (Print): 2211-7385
ISSN (Online): 2211-7393

Nanocarbon Materials for Photodynamic Therapy and Photothermal Therapy

Author(s): Qian Li, Hong Ruan and Hongguang Li

Volume 2, Issue 2, 2014

Page: [58 - 64] Pages: 7

DOI: 10.2174/2211738502666140929211831


Photodynamic therapy (PDT) and photothermal therapy (PTT) are two kinds of methodologies that can be applied to the treatment of cancer. They own some advantages over the existing strategies including chemo- and radiotherapy but at the same time, are also facing big challenges. During the past decades, great efforts have been devoted to overcome the bottlenecks and to push these two newly-emerging methodologies to practical applications. One of the big achievements is the utilization of nanocarbon materials in PDT and PTT. Nanocarbon materials include zero-dimensional fullerene, one-dimensional carbon nanotubes (CNTs), and two-dimensional graphene. Upon illumination, fullerene can generate reactive oxygen species (ROS) through both Type I and Type II photochemistry, which allows it a good candidate for PDT. CNTs and graphene generate significant amount of heat upon excitation with near-infrared light, which makes them suitable for PTT. In this review, recent developments of the application of nanocarbon materials in PDT and PTT are briefly summarized and discussed.

Keywords: Carbon nanotubes, fullerene, graphene, photodynamic therapy, photothermal therapy, tumor.

Graphical Abstract

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