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Mini-Reviews in Organic Chemistry


ISSN (Print): 1570-193X
ISSN (Online): 1875-6298

Cyclobutyl- and Cyclobutenylphosphonates: Synthesis, Transformations and Biological Activities

Author(s): Abed Al Aziz Al Quntar, Morris Srebnik, Alexander O. Terent'ev and Valery M. Dembitsky

Volume 11 , Issue 4 , 2014

Page: [445 - 461] Pages: 17

DOI: 10.2174/1570193X1104140926170132

Price: $65


The synthesis, chemical properties, transformations, and biological activities of mono- and multi- substituted cyclobutyl- and cyclobutenylphosphonates were broadly discussed in this article review. The synthesis of four-membered ring phosphonates was based either on phosphorylation of already constructed cyclobutyl moiety or on inter- and intramolecular cyclizations of phosphorus containing compounds. Also, emphasis was illustrated on the recent development in this field.

Keywords: Four-membered ring, cyclobutanes, cyclobutenes, phosphonates, phosphorylation, phosphonates biological activities.

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