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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

A Facile and Economical Method to Synthesize Vildagliptin

Author(s): Yu Deng, Anmin Wang, Zhu Tao, Yingjie Chen, Xinmei Pan and Xiangnan Hu

Volume 11, Issue 10, 2014

Page: [780 - 784] Pages: 5

DOI: 10.2174/1570178611666140922121805

Price: $65


A mild and economical method to prepare vildagliptin had been reported with a good yield. In this paper, vildagliptin was synthesized from L-proline and 3-amino-1-adamantanol through chloride acetylation, amination, dehydration and substitution. The total yield of the target compound was 59%.

Keywords: Economical, synthesize, vildagliptin.

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