摘要
随着平均寿命的增长及神经退行性疾病的普遍增长,关于认知老化轨迹的调查变得非常热门和充满前途。本项研究的目的是评估居住在中国北京社区居民与年龄相关的认知衰退及认知功能的潜在关联因素。这项研究中,52-88岁年龄段的老人有1248名,其中包括175名轻度认知障碍(MCI)的受试者,接受了一系列神经心理学量表。收集了包括人口统计信息、病史、饮食习惯、生活方式及业余爱好的个人信息。正常志愿者的所有认知功能显示老年性下降。分段线性拟合结果表明直到58岁其听觉词语学习测验保持稳定,随后开始持续下降。50岁初期,处理速度和执行能力开始衰退。66岁之后视觉空间和语言测试得分下降。一般精神状态的衰退阶段是63岁-70岁之间。然而,在大多数的认知测试中,MCI组并没有显示明显的与年龄相关的衰退。多元线性回归分析表明教育、性别、业余活动、糖尿病及饮食习惯与认知能力相关。这些结果表明与年龄相关的多种轨迹横跨多种认知领域。我们发现了MCI与正常老人之间的老年人认知衰退的不同形式。这些发现可以帮助改善认知干预计划的指导,并且对国家政策有一定影响。
关键词: 认知衰退,轻度认知障碍,正常老化,保护因子,危险因素
Current Alzheimer Research
Title:Trajectories of Age-Related Cognitive Decline and Potential Associated Factors of Cognitive Function in Senior Citizens of Beijing
Volume: 11 Issue: 8
Author(s): He Li, Chenlong Lv, Ting Zhang, Kewei Chen, Chuansheng Chen, Guozhong Gai, Liangping Hu, Yongyan Wang and Zhanjun Zhang
Affiliation:
关键词: 认知衰退,轻度认知障碍,正常老化,保护因子,危险因素
摘要: With a longer life expectancy and an increased prevalence of neurodegenerative diseases, investigations on trajectories of cognitive aging have become exciting and promising. This study aimed to estimate the patterns of age-related cognitive decline and the potential associated factors of cognitive function in community-dwelling residents of Beijing, China. In this study, 1248 older adults aged 52-88 years [including 175 mild cognitive impairment (MCI) subjects] completed a battery of neuropsychological scales. The personal information, including demographic information, medical history, eating habits, lifestyle regularity and leisure activities, was also collected. All cognitive function exhibited an agerelated decline in normal volunteers. Piece-wise linear fitting results suggested that performance on the Auditory Verbal Learning Test remained stable until 58 years of age and continued to decline thereafter. The decline in processing speed and executive function began during the early 50’s. Scores on visual-spatial and language tests declined after 66 years of age. The decline stage of the general mental status ranged from 63 to 70 years of age. However, the MCI group did not exhibit an obvious age-related decline in most cognitive tests. Multivariate linear regression analyses indicated that education, gender, leisure activities, diabetes and eating habits were associated with cognitive abilities. These results indicated various trajectories of age-related decline across multiple cognitive domains. We also found different patterns of agerelated cognitive decline between MCI and normal elderly. These findings could help improve the guidance of cognitive intervention program and have implications for public policy issues.
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Cite this article as:
He Li, Chenlong Lv, Ting Zhang, Kewei Chen, Chuansheng Chen , Guozhong Gai, Liangping Hu, Yongyan Wang and Zhang Zhanjun, Trajectories of Age-Related Cognitive Decline and Potential Associated Factors of Cognitive Function in Senior Citizens of Beijing, Current Alzheimer Research 2014; 11 (8) . https://dx.doi.org/10.2174/156720501108140910123112
DOI https://dx.doi.org/10.2174/156720501108140910123112 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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