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Drug Delivery Letters


ISSN (Print): 2210-3031
ISSN (Online): 2210-304X

Formulation and in-vitro Evaluation of a Bilayer Matrix Tablet Containing Aceclofenac as Sustained Release and Paracetamol as Immediate Release

Author(s): Hamid Khan and Javed Ali

Volume 4 , Issue 3 , 2014

Page: [221 - 226] Pages: 6

DOI: 10.2174/2210303104666140909004155

Price: $65


The objective of the present study was to formulate bilayer matrix tablets containing aceclofenac as sustained release and paracetamol as immediate release using HPMC as the matrix forming polymer and the tablets were evaluated via in-vitro studies. In-vitro drug release studies were carried out in hydrochloric acid buffer of pH 1.2 (0.1N) with 1% w/v SLS using USP paddle apparatus. The amount of drugs released at different time intervals were determined by validated UPLC-PDA method. In-vitro drug release from prepared tablets showed better effect when compared with marketed combination tablets. Tablets thus formulated provided sustained release of aceclofenac over a period of 12 h and paracetamol as immediate release within 30 min.

Keywords: Aceclofenac, bilayer tablet, immediate release, paracetamol, sustained release.

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