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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Body Mass Index, Lipid Metabolism and Estrogens: Their Impact on Coronary Heart Disease

Author(s): G.D. Kolovou, V. Kolovou, P.M. Kostakou and S. Mavrogeni

Volume 21 , Issue 30 , 2014

Page: [3455 - 3465] Pages: 11

DOI: 10.2174/0929867321666140901114515

Price: $65

Abstract

Estrogens influence lipid metabolism and body fat distribution in women. Premenopausal women have increased lipoprotein lipase action in abdominal and femoral subcutaneous fat compared with men of the same age. Estrogens may also affect adipose tissue either directly through specific estrogen receptors or indirectly via their effects on other tissues. As adipose tissue produces several cytokines including leptin, adiponectin and interleukin-6, estrogens may alter their levels, thus influencing various biological processes. Lack of estrogens such as in menopause, causes an increase in visceral adiposity, leading to changes in lipid and lipoprotein metabolism. Due to those alterations, postmenopausal women are more prone to coronary heart disease. In this review the influence of estrogens on body mass index, lipid metabolism and some of the therapeutic options will be analyzed.

Keywords: Body fat, coronary heart disease, estrogens, hormone replacement therapy, lipids, menopause.


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