摘要
Spalt( SAL )家族是一类进化上保守的基因,最初在果蝇确定为胚胎发育需要的同源异型基因。在脊椎动物中,sal-like 4(SALL4)特别多的表达在胚胎和成年干细胞/干细胞样细胞。SALL4是一个重要的调节器有助于生物发育细胞的干性和肿瘤生长,因此,SALL4已经成为基因治疗的靶标。此外,许多影响SALL4基因的突变被发现在临床上与一系列的先天性异常关联,如杜安/ 杜安相关综合征,心室中隔缺损,卵巢功能早衰。本综述描述了SALL4关键功能的潜在机制及其作为基因治疗的靶标。最后,我总结和讨论了Sall4的应用及其诊断和治疗人类疾病功能的进展。
关键词: 癌症,杜安综合症,胚胎发育,造血作用,Sall4,干细胞
Current Gene Therapy
Title:SALL4: Engine of Cell Stemness
Volume: 14 Issue: 5
Author(s): Jianhua Xiong
Affiliation:
关键词: 癌症,杜安综合症,胚胎发育,造血作用,Sall4,干细胞
摘要: The spalt (sal) family is a class of evolutionarily conserved genes originally identified in Drosophila as homeotic genes required for embryonic development. In vertebrates, the expression of sal-like 4 (SALL4) is specifically enriched in both embryonic and adult stem/stem-like cells. SALL4 is a master regulator that contributes to cell stemness in biological development and tumor growth. Thus, Sall4 has emerged as a target for gene therapy. In addition, numerous mutations affecting the Sall4 gene have been discovered and clinically linked to a series of congenital abnormalities, such as Duane/Duane-related syndromes, ventricular septal defect and premature ovarian failure. This review delineates the underlying mechanisms of key functions of SALL4 and its use as a target for gene therapy. Finally, I summarize and discuss advances made on the application of Sall4 and its functions in diagnostics and treatments for human diseases.
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Cite this article as:
Xiong Jianhua, SALL4: Engine of Cell Stemness, Current Gene Therapy 2014; 14 (5) . https://dx.doi.org/10.2174/1566523214666140825125138
DOI https://dx.doi.org/10.2174/1566523214666140825125138 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
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