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Current Respiratory Medicine Reviews

Editor-in-Chief

ISSN (Print): 1573-398X
ISSN (Online): 1875-6387

Cofactor Biosynthetic Pathways in Mycobacterium tuberculosis as Potential Drug Targets

Author(s): Shilpika Pandey, Sarthak Gaur, Neha Topno, Sidharth Chopra and Arunava Dasgupta

Volume 10, Issue 2, 2014

Page: [97 - 108] Pages: 12

DOI: 10.2174/1573398X10666140822004506

Price: $65

Abstract

There are many chemotherapeutic interventions available for tuberculosis (TB) and are in use for more than five decades, but still there is an urgent need for novel drugs against new targets due to emergence of resistant strains. Moreover, the ability of Mycobacterium tuberculosis (Mtb) to survive within granulomas in a non-replicating latent stage prolongs the course of drug dose and hence increases the severity of the disease. The significant rerouting of metabolism is one of the key processes that help mycobacteria adapt to the hostile environment of host granuloma. In this review, we are focusing on some of the cofactor biosynthetic pathways of Mycobacterium tuberculosis and their utilization as drug targets.

Keywords: FAD, Mtb, NAD, Pantothenate, iron, vitamin.

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