Abstract
Mucosal administration of vaccines is one of the most popular approaches to induce desired immunity against various types of antigen and microbial in central as well as peripheral blood and in most external mucosal surfaces. The oral route is a preferred choice over parenteral route for this purpose mainly due to an ease of administration and therefore, for the possibility of covering large population for mass immunization. Different strategies of mucosal vaccination aimed to prevent colony formation and infection by pathogens and block its development. But a major concern with these vaccines is the degradation of protein components in stomach due to physiological conditions and gastric enzymes. Therefore, surface modified nanoparticles offer a better and stable alternative for efficient delivery and better activation of required immune responses. Natural and synthetic polymers are used to prepare nanoparticulate carrier systems for the development of oral mucosal vaccines. Amongst these, biodegradable polymers based nano-particulate carriers have been explored extensively for the development of delivery systems. Present review summarizes possible approaches and mechanisms for the systemic immunization by oral vaccines and critically discusses various polymers used, different strategies of surface modification to achieve targeting of antigen loaded nanoparticulate carrier at cellular level that are essentially required for a successful mucosal vaccination approach, and future prospects of nanoparticulate system as adjutants in oral mucosal vaccination.
Keywords: Biodegradable polymers, lectins, mucosal immunization, nanocarriers, nanoparticles, oral vaccines.
Current Drug Delivery
Title:Surface Modified Nanoparticulate Carrier Constructs for Oral Mucosal Vaccine Delivery
Volume: 11 Issue: 6
Author(s): Neeraj Mishra, Devendra Singh, Sandeep Sharma and Ashish Baldi
Affiliation:
Keywords: Biodegradable polymers, lectins, mucosal immunization, nanocarriers, nanoparticles, oral vaccines.
Abstract: Mucosal administration of vaccines is one of the most popular approaches to induce desired immunity against various types of antigen and microbial in central as well as peripheral blood and in most external mucosal surfaces. The oral route is a preferred choice over parenteral route for this purpose mainly due to an ease of administration and therefore, for the possibility of covering large population for mass immunization. Different strategies of mucosal vaccination aimed to prevent colony formation and infection by pathogens and block its development. But a major concern with these vaccines is the degradation of protein components in stomach due to physiological conditions and gastric enzymes. Therefore, surface modified nanoparticles offer a better and stable alternative for efficient delivery and better activation of required immune responses. Natural and synthetic polymers are used to prepare nanoparticulate carrier systems for the development of oral mucosal vaccines. Amongst these, biodegradable polymers based nano-particulate carriers have been explored extensively for the development of delivery systems. Present review summarizes possible approaches and mechanisms for the systemic immunization by oral vaccines and critically discusses various polymers used, different strategies of surface modification to achieve targeting of antigen loaded nanoparticulate carrier at cellular level that are essentially required for a successful mucosal vaccination approach, and future prospects of nanoparticulate system as adjutants in oral mucosal vaccination.
Export Options
About this article
Cite this article as:
Mishra Neeraj, Singh Devendra, Sharma Sandeep and Baldi Ashish, Surface Modified Nanoparticulate Carrier Constructs for Oral Mucosal Vaccine Delivery, Current Drug Delivery 2014; 11 (6) . https://dx.doi.org/10.2174/1567201811666140709112040
DOI https://dx.doi.org/10.2174/1567201811666140709112040 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
Call for Papers in Thematic Issues
Advances of natural products, bio-actives and novel drug delivery system against emerging viral infections
Due to the increasing prevalence of viral infections and the ability of these human pathogens to develop resistance to current treatment strategies, there is a great need to find and develop new compounds to combat them. These molecules must have low toxicity, specific activity and high bioavailability. The most suitable ...read more
Electrospun Fibers as Drug Delivery Systems
In recent years, electrospun fibers have attracted considerable attention as potential platforms for drug delivery due to their distinctive properties and adaptability. These fibers feature a notable surface area-to-volume ratio and can be intentionally designed with high porosity, facilitating an increased capacity for drug loading and rendering them suitable for ...read more
Emerging Nanotherapeutics for Mitigation of Neurodegenerative Disorders
Conditions affecting the central nervous system (CNS) present a significant hurdle due to limited access of both treatments and diagnostic tools for the brain. The blood-brain barrier (BBB) acts as a barrier, restricting the passage of molecules from the bloodstream into the brain. The most formidable challenge facing scientists is ...read more
Nanotechnology Based Chemotherapy for the treatment of Head & Neck Cancer
The escalating recurrence rates observed in Head and Neck cancer, particularly within the chemo-therapeutically treated cohort (50-60%), can be attributed to the non-selective nature of current anticancer drug delivery modalities. In this context, nanotechnology-based drug delivery systems emerge as a promising avenue for achieving precise localization of therapeutic agents to ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Comparison Between the Maximum Standard Uptake Value and the Ratio of Lymph Node to Primary Tumor Attenuation in Head and Neck Cancers: A Prospective Study
Current Medical Imaging Anticancer Mechanisms of Berberine: A Good Choice for Glioblastoma Multiforme Therapy
Current Medicinal Chemistry Developments of Polo-like Kinase 1 (Plk1) Inhibitors as Anti-Cancer Agents
Mini-Reviews in Medicinal Chemistry Synthesis and Anticancer Properties of Novel Truncated Carbocyclic Nucleoside Analogues
Anti-Cancer Agents in Medicinal Chemistry Editorial [Hot topic: Recent Progress in Cancer Therapeutics (Guest Editor: Kurt S. Zaenker)]
Current Molecular Medicine MicroRNAs in Lung Cancer and Lung Cancer Bone Metastases: Biomarkers for Early Diagnosis and Targets for Treatment
Recent Patents on Anti-Cancer Drug Discovery Meet Our Editorial Board Member
The Natural Products Journal COVID-19 Invades Several Important Organs other than the Lungs: Organs Crosstalk
Coronaviruses Curcumin as an Anti-Cancer Agent: Review of the Gap Between Basic and Clinical Applications
Current Medicinal Chemistry Subject index to volume 3
Current Molecular Medicine Synthesis, Immunomodulation and Cytotoxic Effects of Vanadium (IV) Complexes
Medicinal Chemistry Fucose Specific Lectins in Cancer Research and Diagnosis
Drug Design Reviews - Online (Discontinued) Galectin-9 in Cancer Therapy
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Patent Selections
Current Biomarkers (Discontinued) Clinical Evidence of Herb-Drug Interactions: A Systematic Review by the Natural Standard Research Collaboration
Current Drug Metabolism A Novel Synthesis Method of Apogossypolone and its Antitumor Activity
Letters in Drug Design & Discovery Beclin 1 Biology and its Role in Heart Disease
Current Cardiology Reviews Targeting CD4 to Disrupt Signaling Through Membrane Rafts: Towards a Raft-Based Therapeutics
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Anti-cancer Research on Arnebiae radix-derived Naphthoquinone in Recent Five Years
Recent Patents on Anti-Cancer Drug Discovery Design of Novel Chemotherapeutic Agents Targeting Checkpoint Kinase 1 Using 3D-QSAR Modeling and Molecular Docking Methods
Current Computer-Aided Drug Design