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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Perspectives on Tuberculosis Pathogenesis and Discovery of Anti- Tubercular Drugs

Author(s): Fidele Ntie-Kang, Joseph N. Yong, Luc C. Owono Owono, Wolfgang Sippl and Eugene Megnassan

Volume 21 , Issue 30 , 2014

Page: [3466 - 3477] Pages: 12

DOI: 10.2174/0929867321666140706144933

Price: $65

Abstract

Based on the global burden of tuberculosis and resistant strains that have recently emerged, not responding to existing therapies, it has become urgent to search for new remedies against this global human plague that has been compounded by HIV co-infection. Thus, the search for new drugs against the disease-causing agent, Mycobacterium tuberculosis (MTB), is an ongoing effort. This review discusses the state-of-the-art in anti-tuberculosis pathogenesis and anti-TB drug research, identifying some of the challenges being faced by researchers in the field and sheds light on possible ways forward, particularly in low-income countries.

Keywords: Drug discovery, drug resistance, in silico screening, tuberculosis.


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