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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Endothelial Dysfunction in Metabolic Diseases: Role of Oxidation and Possible Therapeutic Employment of N-acetylcysteine

Author(s): A. Masha and V. Martina

Volume 21 , Issue 32 , 2014

Page: [3616 - 3635] Pages: 20

DOI: 10.2174/0929867321666140706132900

Price: $65


Several metabolic diseases present a high cardiovascular mortality due to endothelial dysfunction consequences. In the last years of the past century, it has come to light that the endothelial cells, previously considered as inert in what regards an eventual secretion activity, play a pivotal role in regulating different aspects of the vascular function (endothelial function). It was clearly demonstrated that the endothelium acts as a real active organ, owning endocrine, paracrine and autocrine modulation activities by means of which it is able to regulate the vascular homeostasis. The present review will investigate the relationship between some metabolic diseases and the endothelial dysfunction and in particular the mechanisms underlying the effects of metabolic pathologies on the endothelium. Furthermore, it will consider the possible therapeutic employment of the N-acetilcysteine in such conditions.

Keywords: Antioxidants, cGMP, diabetes mellitus, metabolic syndrome, nitric oxide, N-acetylcysteine, oxidation, oxidative stress, polycystic ovary syndrome, thiols, obesity.

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