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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Telomere Maintenance Mechanisms in Cancer: Clinical Implications

Author(s): Roger R. Reddel

Volume 20, Issue 41, 2014

Page: [6361 - 6374] Pages: 14

DOI: 10.2174/1381612820666140630101047

open access plus

Abstract

The presence of immortal cell populations with an up-regulated telomere maintenance mechanism (TMM) is an almost universal characteristic of cancers, whereas normal somatic cells are unable to prevent proliferation-associated telomere shortening and have a limited proliferative potential. TMMs and related aspects of telomere structure and function therefore appear to be ideal targets for the development of anticancer therapeutics. Such treatments would be targeted to a specific cancer-related molecular abnormality, and also be broad-spectrum in that they would be expected to be potentially applicable to most cancers. However, the telomere biology of normal and malignant human cells is a relatively young research field with large numbers of unanswered questions, so the optimal design of TMM-targeted therapeutic approaches remains unclear. This review outlines the opportunities and challenges presented by telomeres and TMMs for clinical management of cancer.

Keywords: Alternative lengthening of telomeres, cancer, diagnosis, prognosis, telomerase, telomeres, therapy.


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