Telomere Maintenance Mechanisms in Cancer: Clinical Implications

Title:Telomere Maintenance Mechanisms in Cancer: Clinical Implications

Volume: 20 Issue: 41

Author(s): Roger R. Reddel

Affiliation:

• Children's Medical Research Institute, 214 Hawkesbury Road, Westmead, New South Wales 2145, Australia.,Australia

Keywords: Alternative lengthening of telomeres, cancer, diagnosis, prognosis, telomerase, telomeres, therapy.

Abstract: The presence of immortal cell populations with an up-regulated telomere maintenance mechanism (TMM) is an almost universal characteristic of cancers, whereas normal somatic cells are unable to prevent proliferation-associated telomere shortening and have a limited proliferative potential. TMMs and related aspects of telomere structure and function therefore appear to be ideal targets for the development of anticancer therapeutics. Such treatments would be targeted to a specific cancer-related molecular abnormality, and also be broad-spectrum in that they would be expected to be potentially applicable to most cancers. However, the telomere biology of normal and malignant human cells is a relatively young research field with large numbers of unanswered questions, so the optimal design of TMM-targeted therapeutic approaches remains unclear. This review outlines the opportunities and challenges presented by telomeres and TMMs for clinical management of cancer.

Cite this article as:

Reddel R. Roger, Telomere Maintenance Mechanisms in Cancer: Clinical Implications, Current Pharmaceutical Design 2014; 20(41) . https://dx.doi.org/10.2174/1381612820666140630101047