Abstract
The discovery of novel nucleic acid folding architectures bears a twofold interest related to the structural properties of unprecedented forms and to their functional significance. In addition, physiologically and pathologically important processes can be impaired by endogenous or xenobiotic ligands interacting with specific target sequences. In this paper we will focus on recent advances in the study of telomeric G-quadruplex DNA and RNA structures and the rational design and development of synthetic ligands aimed at pharmacological applications.
Keywords: G-quadruplex ligand, G-quadruplex structure, Telomere.
Current Pharmaceutical Design
Title:Telomeric G-Quadruplex Architecture and Interactions with Potential Drugs
Volume: 20 Issue: 41
Author(s): Claudia Sissi and Manlio Palumbo
Affiliation:
Keywords: G-quadruplex ligand, G-quadruplex structure, Telomere.
Abstract: The discovery of novel nucleic acid folding architectures bears a twofold interest related to the structural properties of unprecedented forms and to their functional significance. In addition, physiologically and pathologically important processes can be impaired by endogenous or xenobiotic ligands interacting with specific target sequences. In this paper we will focus on recent advances in the study of telomeric G-quadruplex DNA and RNA structures and the rational design and development of synthetic ligands aimed at pharmacological applications.
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Cite this article as:
Sissi Claudia and Palumbo Manlio, Telomeric G-Quadruplex Architecture and Interactions with Potential Drugs, Current Pharmaceutical Design 2014; 20 (41) . https://dx.doi.org/10.2174/1381612820666140630094300
DOI https://dx.doi.org/10.2174/1381612820666140630094300 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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