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Current Diabetes Reviews


ISSN (Print): 1573-3998
ISSN (Online): 1875-6417

Diabetes Mellitus Induced Impairment of Male Reproductive Functions: A Review

Author(s): Ram Niwas Jangir and Gyan Chand Jain

Volume 10 , Issue 3 , 2014

Page: [147 - 157] Pages: 11

DOI: 10.2174/1573399810666140606111745

Price: $65


Diabetes mellitus (DM) represents one of the greatest threats to human health all over the world. The incidence of DM is rising rapidly also including children and young persons of reproductive age. Diabetes has been associated with reproductive impairment in both men and women. Diabetes may affect male reproductive functions at multiple levels as a result of its effects on the endocrine control of spermatogenesis, steroidogenesis, sperm maturation, impairment of penile erection and ejaculation. A large number of studies both on diabetic men and experimental diabetic animals have been published on the impact of DM on male reproductive functions during the past few years but many of them have conflicting results. The present review summarizes the research finding of a large number of research papers on the reproductive functions especially on hypothalmo-pituitary-gonadal axis, spermatogenesis, histopathology of testis, synthesis and secretion of testosterone, sperm quality, ejaculatory function and fertility both in diabetic men and experimental diabetic animals.

Keywords: Diabetes, fertility, oxidative stress, spermatogenesis, sperm quality, testosterone.

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