Boronic Acid-based Enzyme Inhibitors: A Review of Recent Progress

Title:Boronic Acid-based Enzyme Inhibitors: A Review of Recent Progress

Volume: 21 Issue: 28

Author(s): H. Fu, H. Fang, Jie Sun, H. Wang, A. Liu, J. Sun and Z. Wu

Affiliation:

• Institute of Materia Medica, Shandong Academy of Medical Sciences, 18877 Jingshi Rd., Ji’nan, Shandong 250062, China.,China

Keywords: Boronic acid, bortezomib, enzyme inhibitor, HDACs, proteasome inhibitor, serine protease.

Abstract: Since Bortezomib was approved by US FDA as the first drug to treat multiple myeloma, various boronic acid compounds have been developed as enzyme inhibitors. This paper reviewed the progress of boronic acid-based inhibitors against enzymes including proteasome, serine protease, HDACs and other enzymes in the past decade.

Cite this article as:

Fu H., Fang H., Sun Jie, Wang H., Liu A., Sun J. and Wu Z., Boronic Acid-based Enzyme Inhibitors: A Review of Recent Progress, Current Medicinal Chemistry 2014; 21(28) . https://dx.doi.org/10.2174/0929867321666140601200803