Abstract
Triazoles and their derivatives have been widely utilized as precursors in the syntheses of biologically active systems such as anticancers, antimicrobials, antifungals and other cytotoxic active agents. In this review, we tried to highlight the recent advances (2010- 2013) in the syntheses of 1,2,3-triazoles, bis-1,2,3-triazoles and fused triazoles via click reaction. Click reaction provides substances quickly and reliably by combining small units together. Click chemistry can also be applied widely for the syntheses of biologically active compounds. Since the 1,2,3-triazole scaffold is present in many beneficial biologically structures, we hope this review attracts the attentions of synthetic organic chemists to make use of the advantages of click reaction in the total syntheses of natural products containing 1,2,3-triazoles.
Keywords: 1, 2, 3-triazoles, azides, bis-1, 2, 3-triazoles, click reaction, cycloaddition, heterocycles, fused 1, 2, 3-triazoles.
Current Organic Synthesis
Title:Recent Applications of Click Reaction in the Syntheses of 1,2,3-triazoles
Volume: 11 Issue: 5
Author(s): Majid M. Heravi, Hoda Hamidi and Vahideh Zadsirjan
Affiliation:
Keywords: 1, 2, 3-triazoles, azides, bis-1, 2, 3-triazoles, click reaction, cycloaddition, heterocycles, fused 1, 2, 3-triazoles.
Abstract: Triazoles and their derivatives have been widely utilized as precursors in the syntheses of biologically active systems such as anticancers, antimicrobials, antifungals and other cytotoxic active agents. In this review, we tried to highlight the recent advances (2010- 2013) in the syntheses of 1,2,3-triazoles, bis-1,2,3-triazoles and fused triazoles via click reaction. Click reaction provides substances quickly and reliably by combining small units together. Click chemistry can also be applied widely for the syntheses of biologically active compounds. Since the 1,2,3-triazole scaffold is present in many beneficial biologically structures, we hope this review attracts the attentions of synthetic organic chemists to make use of the advantages of click reaction in the total syntheses of natural products containing 1,2,3-triazoles.
Export Options
About this article
Cite this article as:
Heravi M. Majid, Hamidi Hoda and Zadsirjan Vahideh, Recent Applications of Click Reaction in the Syntheses of 1,2,3-triazoles, Current Organic Synthesis 2014; 11 (5) . https://dx.doi.org/10.2174/1570179411666140530210314
DOI https://dx.doi.org/10.2174/1570179411666140530210314 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
Call for Papers in Thematic Issues
Exploring the Role of Chemical Graph Theory in Advancing Current Organic Synthesis
Organic synthesis is a fundamental discipline in chemistry, crucial for the creation of complex molecules with diverse applications in pharmaceuticals, materials science, and beyond. However, the process of designing efficient synthetic routes for target molecules remains challenging. Chemical graph theory, a branch of theoretical chemistry, offers powerful tools for understanding ...read more
Photoswitches for Molecular Recognition
This Special Issue would cover the hot topics on synthesis and chemical and photophysical characterization of new photoswitchable derivatives and their applications on molecular recognition of metabolites and biological active compounds, both in physiological medium and in living cells. Photoswitches are compounds that can change their conformation or properties in ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Virtual Screening Strategies in Medicinal Chemistry: The State of the Art and Current Challenges
Current Topics in Medicinal Chemistry Homology Models in Docking and High-Throughput Docking
Current Topics in Medicinal Chemistry Recent Developments of Thalidomide Derivatives Possessing Anti-Inflammatory Activity
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Isoniazid Induced Convulsions at Therapeutic Dose in an Alcoholic and Smoker Patient
Current Drug Safety Chemotherapeutic Strategies Against Trypanosoma brucei: Drug Targets vs. Drug Targeting
Current Pharmaceutical Design Piperidin-4-one: The Potential Pharmacophore
Mini-Reviews in Medicinal Chemistry Conjugated Diyne Chemistry: Synthesis, Natural Existence and Applications
Current Organocatalysis Novel Antibacterial Compounds and their Drug Targets - Successes and Challenges
Current Medicinal Chemistry 3-(1-Adamantylthio)-4-Phenylpyridine as a Potential Therapeutic for Methicillin-Resistant Staphylococcus aureus
Letters in Drug Design & Discovery Organic Toxins as Tools to Understand Ion Channel Mechanisms and Structure
Current Topics in Medicinal Chemistry Docking and PLS Studies on a Set of Thiophenes RNA Polymerase Inhibitors Against Staphylococcus aureus
Current Topics in Medicinal Chemistry Regulation of Cell Wall Synthesis and Growth
Current Molecular Medicine Design, Synthesis and Antimycobacterial Activity of Some New Pyridazine Derivatives: Bis-pyridazine. Part IV<sup>12-14</sup>
Infectious Disorders - Drug Targets Immunotherapeutic Impact of Toll-like Receptor Agonists in Breast Cancer
Anti-Cancer Agents in Medicinal Chemistry Role of CD73 in Disease: Promising Prognostic Indicator and Therapeutic Target
Current Medicinal Chemistry A New Catalytic Method for Eco-Friendly Synthesis of Quinoxalines by Zirconium (IV) Oxide Chloride Octahydrate Under Mild Conditions
Letters in Organic Chemistry Lipid-Drug Conjugates for Oral Bioavailability Enhancement
Recent Patents on Nanomedicine Exploring and Prioritization of Mobile-Based Self-Management Strategies for HIV Care
Infectious Disorders - Drug Targets Design and Synthesis of (<i>E</i>)-4-(2-Phenyl-2<i>H</i>-chromen-3-yl)but-3-en-2-ones and Evaluation of their <i>In Vitro</i> Antimicrobial Activity
Letters in Organic Chemistry Therapeutic Applications of Nanoemulsion Based Drug Delivery Systems: A Review of Patents in Last Two Decades
Recent Patents on Drug Delivery & Formulation