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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

The Effects of Caffeine on the Cholinergic System

Author(s): Miroslav Pohanka

Volume 14, Issue 6, 2014

Page: [543 - 549] Pages: 7

DOI: 10.2174/1389557514666140529223436

Price: $65


Caffeine is a secondary metabolite of tea and coffee plants. It is the active psychostimulant ingredient of widely consumed beverages, chocolate and some drugs as well. The major pathways for caffeine including interaction with adenosine receptors have been identified but caffeine has several minor pathways as well that remain poorly understood including the cholinergic system. Given the role of caffeine in the cholinergic system, some molecular targets have been tracked and a mechanism of its action has been proposed in research studies. However, the biological effect of caffeine on the cholinergic system is not completely understood. The present review focuses on the role of caffeine in the cholinergic system.

Keywords: Acetylcholine, acetylcholinesterase, acetylcholine receptor, butyrylcholinesterase, caffeine, cholinergic antiinflammatory pathway.

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