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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

New Drugs for HDL-C Disorders: The Beginning

Author(s): MyNgan Duong and Stephen J. Nicholls

Volume 21 , Issue 25 , 2014

Page: [2947 - 2951] Pages: 5

DOI: 10.2174/0929867321666140414104130

Price: $65


For more than 20 years there has been increasing interest in the development of novel therapies to raise levels of high-density lipoprotein cholesterol (HDL-C). However, well publicized failures of recent clinical trials of agents that raise HDL-C levels have stimulated considerable controversy with regard to the potential clinical utility of this therapeutic target. A number of classes of agents are currently under investigation with variable effects on HDL quantity and quality. These will be reviewed.

Keywords: Atherosclerosis, cardiovascular disease, HDL, lipids, risk factors.

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