Abstract
Recent developments in the microwave-assisted synthesis of carbo- and heterocyclicsystems are reviewed with the focus on diversity-oriented cycloaddition reactions. Ineed, these reactions represent one of the most important endeavors in chemistry and are of considerable interest in the synthesis of carbo-and heterocyclic compounds from simple unsaturated systems, and allow the creation of more than two bonds in one step. This review summarizes recent literature (2006-2013) on advances regarding [3+2], [4+2] and [2+2] cycloadditions including their miscellaneous version. Advantages of microwave dielectric heating are highlighted by comparison with conventional thermal conditions. In particular, we describe here the microwave effect, reaction media including solvent-free transformations and more ecological processes in the context of green and environmentally benign chemistry.
Keywords: [2+2] cycloaddition, 1, 3-dipolar cycloaddition, carbocycles, diels-alder, green catalysis, green chemistry, heterocycles, microwave synthesis.
Current Organic Chemistry
Title:Microwave-assisted Cycloaddition Reactions in Carbo- and Heterocyclic Chemistry
Volume: 18 Issue: 16
Author(s): Aziza Saber, Hamid Marzag, Rachid Benhida and Khalid Bougrin
Affiliation:
Keywords: [2+2] cycloaddition, 1, 3-dipolar cycloaddition, carbocycles, diels-alder, green catalysis, green chemistry, heterocycles, microwave synthesis.
Abstract: Recent developments in the microwave-assisted synthesis of carbo- and heterocyclicsystems are reviewed with the focus on diversity-oriented cycloaddition reactions. Ineed, these reactions represent one of the most important endeavors in chemistry and are of considerable interest in the synthesis of carbo-and heterocyclic compounds from simple unsaturated systems, and allow the creation of more than two bonds in one step. This review summarizes recent literature (2006-2013) on advances regarding [3+2], [4+2] and [2+2] cycloadditions including their miscellaneous version. Advantages of microwave dielectric heating are highlighted by comparison with conventional thermal conditions. In particular, we describe here the microwave effect, reaction media including solvent-free transformations and more ecological processes in the context of green and environmentally benign chemistry.
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Cite this article as:
Saber Aziza, Marzag Hamid, Benhida Rachid and Bougrin Khalid, Microwave-assisted Cycloaddition Reactions in Carbo- and Heterocyclic Chemistry, Current Organic Chemistry 2014; 18 (16) . https://dx.doi.org/10.2174/1385272819666140407213427
DOI https://dx.doi.org/10.2174/1385272819666140407213427 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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