Amiodarone-Induced SIADH: Two Cases Report

Title:Amiodarone-Induced SIADH: Two Cases Report

Volume: 14 Issue: 2

Author(s): Michele Iovino, Nicola Iovine, Antonio Petrosino, Brunella Licchelli, Vito A. Giagulli, Massimo Iacoviello, Edoardo Guastamacchia and Vincenzo Triggiani

Affiliation:

Keywords: Amiodarone, aquaporin-2, hyponatremia, hypothyroidism, renal collecting ducts, SIADH.

Abstract: Amiodarone-induced SIADH is a rare but serious side effect of this drug. We report two cases of mild hyponatremia, observed in the last five years, and discuss the role played by age, sex and dose of amiodarone as well as the influence that this molecule may have on aquaporin-2 water channel expression in the renal collecting ducts.

Cite this article as:

Iovino Michele, Iovine Nicola, Petrosino Antonio, Licchelli Brunella, Giagulli A. Vito, Iacoviello Massimo, Guastamacchia Edoardo and Triggiani Vincenzo, Amiodarone-Induced SIADH: Two Cases Report, Endocrine, Metabolic & Immune Disorders - Drug Targets 2014; 14 (2) . https://dx.doi.org/10.2174/1871530314666140407111410