Abstract
Organic chemists utilize azide synthons to generate a wide variety of functionalities, such as triazoles, tetrazoles, and diazo compounds. Though these products are often pharmacophores for biologically active molecules, the potentially hazardous nature of azides can act as a deterrent to their use in conventional reaction settings as they and diazo compounds are both explosive and toxic. Consequently, safer and greener methods of handling such reagents are needed and are being pursued. Among emerging methods are technology assisted syntheses by means of continuous flow processes, and processes where the compounds are generated in situ, eliminating the need for isolation. Additionally, new diazo-transfer agents have been developed that utilize polymer supports to minimize handling concerns. This mini-review will highlight recent advances in the field.
Keywords: Azide, click chemistry, continuous flow, diazo transfer, green chemistry, microreactor, triazole.
Current Organic Synthesis
Title:Safer, Greener, and More Facile Alternatives for Synthesis with Organic Azides
Volume: 11 Issue: 5
Author(s): Meaghan M. Sebeika and Graham B. Jones
Affiliation:
Keywords: Azide, click chemistry, continuous flow, diazo transfer, green chemistry, microreactor, triazole.
Abstract: Organic chemists utilize azide synthons to generate a wide variety of functionalities, such as triazoles, tetrazoles, and diazo compounds. Though these products are often pharmacophores for biologically active molecules, the potentially hazardous nature of azides can act as a deterrent to their use in conventional reaction settings as they and diazo compounds are both explosive and toxic. Consequently, safer and greener methods of handling such reagents are needed and are being pursued. Among emerging methods are technology assisted syntheses by means of continuous flow processes, and processes where the compounds are generated in situ, eliminating the need for isolation. Additionally, new diazo-transfer agents have been developed that utilize polymer supports to minimize handling concerns. This mini-review will highlight recent advances in the field.
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Cite this article as:
Sebeika M. Meaghan and Jones B. Graham, Safer, Greener, and More Facile Alternatives for Synthesis with Organic Azides, Current Organic Synthesis 2014; 11 (5) . https://dx.doi.org/10.2174/1570179411666140328221938
DOI https://dx.doi.org/10.2174/1570179411666140328221938 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
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Organic synthesis is a fundamental discipline in chemistry, crucial for the creation of complex molecules with diverse applications in pharmaceuticals, materials science, and beyond. However, the process of designing efficient synthetic routes for target molecules remains challenging. Chemical graph theory, a branch of theoretical chemistry, offers powerful tools for understanding ...read more
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