Keratin-Based Biomaterials for Biomedical Applications

Title:Keratin-Based Biomaterials for Biomedical Applications

Volume: 15 Issue: 5

Author(s): George Dan Mogosanu, Alexandru Mihai Grumezescu and Mariana Carmen Chifiriuc

Affiliation:

• Department of Science and Engineering of Oxidice Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 1–7 Polizu Street, 011061 Bucharest, Romania.,Oman

Keywords: Drug delivery, keratin, modern systems, nanobiotechnology, pharmaceutical technology, sustainability.

Abstract: The ongoing development of manufacturing technologies and of biocompatible and biodegradable polymers have significantly contributed to the progress of drug delivery systems. In the last decades, the knowledge on keratins has significantly increased, regarding their ultrastructure, molecular and cell biology, physiological and pathological roles, as well as their practical applications in the biomedical field. Produced through sustainable, simple and cheap methods, the natural, non-toxic keratin is one of the raw biomaterials frequently used in the pharmaceutical technology for different applications. The purpose of this review is to present the keratins ultrastructure, types, biological distribution, tissue expression profiles, some of their multiple physiological and pathological roles, as well as their practical applications in drug delivery and cellular and tissue engineering.

Cite this article as:

Mogosanu Dan George, Grumezescu Mihai Alexandru and Chifiriuc Carmen Mariana, Keratin-Based Biomaterials for Biomedical Applications, Current Drug Targets 2014; 15(5) . https://dx.doi.org/10.2174/1389450115666140307154143