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Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Label-Free Cell Phenotypic Drug Discovery

Author(s): Ye Fang

Volume 17, Issue 7, 2014

Page: [566 - 578] Pages: 13

DOI: 10.2174/1386207317666140211100000

Price: $65

Abstract

Phenotypic screen holds great potential in the discovery of new small molecule probes and drugs, as it permits interrogating small molecules with native targets and pathways in model organisms and disease relevant cells. In recent years, label-free cell phenotypic profiling has emerged as an alternative for drug discovery. This paper provides the rationale for phenotypic screens, discusses the basics of label-free cell phenotypic profiling technologies, and provides some guidelines as to how to use these techniques to facilitate drug discovery.

Keywords: Label-free cell phenotypic screen, phenotypic screen, polypharmacology, target-directed drug discovery.


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