Microtubule-targeting Anticancer Agents from Marine Natural Substance

Title:Microtubule-targeting Anticancer Agents from Marine Natural Substance

Volume: 14 Issue: 3

Author(s): Zhiguo Liu, Pengfei Xu, Tao Wu and Wenbin Zeng

Affiliation:

Keywords: Anticancer, marine, microtubule, natural products.

Abstract: Effective novel therapeutics is urgently needed due to increasing incidence of malignant cancer and drug multi-resistance. Natural products and their derivatives have historically been a source of pharmaceutical leads and therapeutic drugs. Microtubuletargeting compounds are among the most promising candidates in the combat against cancer. In particular, marine natural products (MNPs) have demonstrated exceptional potency and potential as anticancer agents. Drug discovery from MNPs provides a new pathway to develop original anticancer agents. In this review, seven classes of typical MNPs with diverse structures are summarized. Bioactive marine compounds isolated from different organisms including invertebrate animals, algae, fungi and bacteria are also discussed.

Cite this article as:

Liu Zhiguo, Xu Pengfei, Wu Tao and Zeng Wenbin, Microtubule-targeting Anticancer Agents from Marine Natural Substance, Anti-Cancer Agents in Medicinal Chemistry 2014; 14(3) . https://dx.doi.org/10.2174/187152061403140207163402