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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Peptide-Based Nanostructures for Cancer Diagnosis and Therapy

Author(s): Linna An, M. Rehan H. Shah Gilani and Gaolin Liang

Volume 21 , Issue 21 , 2014

Page: [2453 - 2466] Pages: 14

DOI: 10.2174/0929867321666140205140600

Price: $65


Peptide-based nanoparticles (pep-NPs) are emerging as promising imaging and therapeutic agents against cancer due to their biocompatibility and tunability. Optimized design of the peptide sequence and moderate conjugation of the sequence with extraneous molecules are crucial to the performance of the inherent properties of pep-NPs such as nanostructure formation and ability of drug delivery. Meanwhile, the peptide sequences based on natural/unnatural amino acids could be utilized for designing nanostructures susceptive/resistant to specific enzymes. Herein, we firstly summarize the basic peptide structures to provide a whole image of pep-NPs. Subsequently, the diagnostic strategies based on different imaging modalities and recent therapeutic applications of pep-NPs for cancer are reviewed.

Keywords: Cancer, diagnosis, drug delivery, imaging, peptide-based nanoparticles, therapy.

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