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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Recent Progress in Asymmetric Fluorination and Trifluoromethylation Reactions

Author(s): Vincent Bizet, Tatiana Besset, Jun-An Ma and Dominique Cahard

Volume 14, Issue 7, 2014

Page: [901 - 940] Pages: 40

DOI: 10.2174/1568026614666140202205531

Price: $65

Abstract

All domains of society are impacted by fluorine chemistry. In particular, fluorine plays a key role in medicinal, pharmaceutical and agrochemical sciences in which the synthesis and evaluation of molecules featuring one or more fluorine atoms is nowadays routine in every new discovery and development program. Since the beginning of this century, enantiopure fluorinated molecules are at the forefront of innovation of the tremendous achievements in fluorine chemistry. This review introduces the reader to the recent progress in asymmetric installation of one fluorine and a trifluoromethyl group via nucleophilic, electrophilic and radical diastereo- and enantioselective reactions.

Keywords: Fluorine, fluorination, trifluoromethylation, chirality, asymmetric synthesis.

Graphical Abstract

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