Abstract
The physiological importance of proteins that can regulate ion balance and transmembrane transport is highlighted by different diseases where ion channel dysfunction is observed. During the past two decades, considerable effort has been devoted to develop synthetic ionophores that can insert or cross cell membranes and restore the dysfunction of highly complex protein channels.
Not withstanding the remarkable structural advances made, only a few classes of synthetic ionophores were studied in complex with proand eukaryote cells in order to obtain information about their biological activity and potential application in ion channel replacement therapy, anti-cancer therapy or antimicrobial treatments. However, only a few synthetic ionophores showed promising biological activity in cellular assays. This review aims to show the utility of synthetic ionophores for different biological applications, including: restoring ion concentration, inducing cell death in different cancer cells, and protecting against a variety of pathogenic microbes. Because the activities of these ionophores depend primarily on their overall physicochemical properties and structure, we discuss here specific functional units and scaffolds that are important for obtaining selective, non-toxic transporters for specific biological applications.
Keywords: Anionophores, anion transporters, biological applications.
Current Organic Chemistry
Title:Biologically Active Synthetic Anionophores
Volume: 18 Issue: 11
Author(s): Andreea R. Schmitzer, Claude-Rosny Elie, Marc Vidal, Mathieu Charbonneau and Audrey Hebert
Affiliation:
Keywords: Anionophores, anion transporters, biological applications.
Abstract: The physiological importance of proteins that can regulate ion balance and transmembrane transport is highlighted by different diseases where ion channel dysfunction is observed. During the past two decades, considerable effort has been devoted to develop synthetic ionophores that can insert or cross cell membranes and restore the dysfunction of highly complex protein channels.
Not withstanding the remarkable structural advances made, only a few classes of synthetic ionophores were studied in complex with proand eukaryote cells in order to obtain information about their biological activity and potential application in ion channel replacement therapy, anti-cancer therapy or antimicrobial treatments. However, only a few synthetic ionophores showed promising biological activity in cellular assays. This review aims to show the utility of synthetic ionophores for different biological applications, including: restoring ion concentration, inducing cell death in different cancer cells, and protecting against a variety of pathogenic microbes. Because the activities of these ionophores depend primarily on their overall physicochemical properties and structure, we discuss here specific functional units and scaffolds that are important for obtaining selective, non-toxic transporters for specific biological applications.
Export Options
About this article
Cite this article as:
Schmitzer R. Andreea, Elie Claude-Rosny, Vidal Marc, Charbonneau Mathieu and Hebert Audrey, Biologically Active Synthetic Anionophores, Current Organic Chemistry 2014; 18 (11) . https://dx.doi.org/10.2174/1385272819666140201002503
DOI https://dx.doi.org/10.2174/1385272819666140201002503 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Mitochondria in Cancer Stem Cells: A Target for Therapy
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Clinical Aspects of Clara Cell 10-kDa Protein / Uteroglobin (Secretoglobin 1A1)
Current Pharmaceutical Design Tissue-Based Approaches to Study Pharmacodynamic Endpoints in Early Phase Oncology Clinical Trials
Current Drug Targets Enzymes To Die For: Exploiting Nucleotide Metabolizing Enzymes for Cancer Gene Therapy
Current Gene Therapy A Novel Quinoline Based Second-generation mTOR Inhibitor that Induces Apoptosis and Disrupts PI3K-Akt-mTOR Signaling in Human Leukemia HL-60 Cells
Anti-Cancer Agents in Medicinal Chemistry Transcriptomic Effects of Estrogen Starvation and Induction in the MCF7 Cells. The Meta-analysis of Microarray Results
Current Pharmaceutical Biotechnology In Situ Modulation of Oxidative Stress: A Novel and Efficient Strategy to Kill Cancer Cells
Current Medicinal Chemistry Cytochrome P450 in Neurological Disease
Current Drug Metabolism Imaging Cellular Receptors in Breast Cancers: An Overview
Current Pharmaceutical Biotechnology Patent Selections:
Recent Patents and Topics on Imaging (Discontinued) The Emerging Role of microRNA in Stroke
Current Topics in Medicinal Chemistry Bone: A Fertile Soil for Cancer Metastasis
Current Drug Targets Delta Np63 alpha – Responsive microRNA Modulate the Expression of Metabolic Enzymes
Current Pharmaceutical Biotechnology An Evolving Role of Piperazine Moieties in Drug Design and Discovery
Mini-Reviews in Medicinal Chemistry MDMA Administration and Heat Shock Proteins Response: Foreseeing a Molecular Link
Current Pharmaceutical Biotechnology Apoptosis and Autophagy Induction As Mechanism of Cancer Prevention by Naturally Occurring Dietary Agents
Current Drug Targets ATRA Entrapped in DSPC Liposome Enhances Anti-metastasis Effect on Lung and Liver During B16F10 Cell Line Metastasis in C57BL6 Mice
Anti-Cancer Agents in Medicinal Chemistry An Overview of Targeting Legumain for Inhibiting Cancers
Current Pharmaceutical Design Anti-inflammatory Phytochemicals for Chemoprevention of Colon Cancer
Current Cancer Drug Targets Inflammation, Serotonin and Major Depression
Current Drug Targets