Synthesis and Anti-Cancer Activities of Aryl Benzyl Ethers with Fluoro Substituents

Title:Synthesis and Anti-Cancer Activities of Aryl Benzyl Ethers with Fluoro Substituents

Volume: 11 Issue: 6

Author(s): Yi Jiang, Hong Xu, Li Liu, Rui He, Xiaomei Song and Na Li

Affiliation:

Keywords: Cancer, Drug design, Anti-cancer activity, Aryl benzyl ethers, Fluoro substituents, Structure-activity relationship.

Abstract: A series of aryl benzyl ethers with fluoro substituents were synthesized and their structures were confirmed by spectral. All the compounds were tested for their cytotoxic activity in vitro against two human tumor cell lines: A549, SGC7901, and most showed cytotoxicity. Compound 10 was the most active in suppressing the growth of both screened cancer cells.

Cite this article as:

Jiang Yi, Xu Hong, Liu Li, He Rui, Song Xiaomei and Li Na, Synthesis and Anti-Cancer Activities of Aryl Benzyl Ethers with Fluoro Substituents, Letters in Drug Design & Discovery 2014; 11(6) . https://dx.doi.org/10.2174/1570180811666140130232233