Generic placeholder image

Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Synthesis and Anti-Cancer Activities of Aryl Benzyl Ethers with Fluoro Substituents

Author(s): Yi Jiang, Hong Xu, Li Liu, Rui He, Xiaomei Song and Na Li

Volume 11, Issue 6, 2014

Page: [736 - 741] Pages: 6

DOI: 10.2174/1570180811666140130232233

Price: $65


A series of aryl benzyl ethers with fluoro substituents were synthesized and their structures were confirmed by spectral. All the compounds were tested for their cytotoxic activity in vitro against two human tumor cell lines: A549, SGC7901, and most showed cytotoxicity. Compound 10 was the most active in suppressing the growth of both screened cancer cells.

Keywords: Cancer, Drug design, Anti-cancer activity, Aryl benzyl ethers, Fluoro substituents, Structure-activity relationship.

Graphical Abstract

Rights & Permissions Print Export Cite as
© 2023 Bentham Science Publishers | Privacy Policy