Abstract
The chronic inflammation associated with asthma leads to remodeling of the lung resulting in bronchoconstriction from airway hyperresponsiveness and progressive airway narrowing. Although the inflammation related to asthma affects the epithelial lining, basement membrane and vascular supply of the airway, its affect on the airway smooth muscle ultimately leads to both acute bronchoconstriction and progressive airway obstruction. Current therapies, including inhaled corticosteroids and long-acting β2-adrenergic agonists, do not conclusively alter the remodeling of the lung tissue related to asthma. The direct application of thermal energy to the airway, termed bronchial thermoplasty, has been demonstrated to reduce the thickness and responsiveness of airway smooth muscle, as well as reduce the incidence of acute exacerbations related to bronchoconstriction and improve progressive airway obstruction.
Keywords: Airway hyperresponsiveness, airway narrowing, asthma, bronchial thermoplasty, chronic inflammation, inflammatory-mediated remodeling, smooth muscle hypertrophy.
Current Respiratory Medicine Reviews
Title:Asthma, Airway Smooth Muscle Cell, and Bronchial Thermoplasty
Volume: 9 Issue: 4
Author(s): Gary M. Idelchik
Affiliation:
Keywords: Airway hyperresponsiveness, airway narrowing, asthma, bronchial thermoplasty, chronic inflammation, inflammatory-mediated remodeling, smooth muscle hypertrophy.
Abstract: The chronic inflammation associated with asthma leads to remodeling of the lung resulting in bronchoconstriction from airway hyperresponsiveness and progressive airway narrowing. Although the inflammation related to asthma affects the epithelial lining, basement membrane and vascular supply of the airway, its affect on the airway smooth muscle ultimately leads to both acute bronchoconstriction and progressive airway obstruction. Current therapies, including inhaled corticosteroids and long-acting β2-adrenergic agonists, do not conclusively alter the remodeling of the lung tissue related to asthma. The direct application of thermal energy to the airway, termed bronchial thermoplasty, has been demonstrated to reduce the thickness and responsiveness of airway smooth muscle, as well as reduce the incidence of acute exacerbations related to bronchoconstriction and improve progressive airway obstruction.
Export Options
About this article
Cite this article as:
Idelchik M. Gary, Asthma, Airway Smooth Muscle Cell, and Bronchial Thermoplasty, Current Respiratory Medicine Reviews 2013; 9 (4) . https://dx.doi.org/10.2174/1573398X10666140115233734
DOI https://dx.doi.org/10.2174/1573398X10666140115233734 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
Call for Papers in Thematic Issues
Exposure to PM2.5 components is associated with respiratory diseases
Through continuous research on the relationship between risk factors and health, it has been found that air pollution, especially atmospheric particulate matter pollution, has become one of the main sources of global disease burden. From 1990 to 2022, the concentration of atmospheric particulate matter pollution has increased by more than ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Mycoplasma pneumoniae: Does it have a Role in Asthma Pathogenesis?
Current Pediatric Reviews Phytochemistry and Phytotherapeutic Aspects of <i>Elaeagnus angustifolia L.</i>
Current Drug Discovery Technologies Cachexia and Herbal Medicine: Perspective
Current Pharmaceutical Design The Need to Consider Context in the Evaluation of Anti-infectious and Immunomodulatory Effects of Vitamin A and its Derivatives
Current Drug Targets Editorial: (Thematic Issue: Autoimmune diseases: What have we learned from mice?)
Current Pharmaceutical Design PET Radioligands for In Vivo Visualization of Neuroinflammation
Current Pharmaceutical Design Quorum-Sensing Inhibitors and Biofilms
Anti-Infective Agents in Medicinal Chemistry Medicinal Chemistry Approaches of Controlling Gastrointestinal Side Effects of Non-Steroidal Anti-Inflammatory Drugs. Endogenous Protective Mechanisms and Drug Design
Medicinal Chemistry Modulation of GSTP1-1 Oligomerization by Electrophilic Inflammatory Mediators and Reactive Drugs
Inflammation & Allergy - Drug Targets (Discontinued) Targeted Drug Delivery Systems for Lung Macrophages
Current Drug Targets Non-Analgesic Effects of Opioids: Opioid-induced Respiratory Depression
Current Pharmaceutical Design Tachykinins and the Cardiovascular System
Current Drug Targets TRPM8: From Cold to Cancer, Peppermint to Pain
Current Pharmaceutical Biotechnology Silybin and Silymarin - New and Emerging Applications in Medicine
Current Medicinal Chemistry Drugs that Target Lipoxygenases and Leukotrienes as Emerging Therapies for Asthma and Cancer
Current Drug Targets - Inflammation & Allergy Quilizumab is an Afucosylated Humanized Anti-M1 Prime Therapeutic Antibody
Clinical Anti-Inflammatory & Anti-Allergy Drugs (Discontinued) Personalised Genetic Intervention for Duchenne Muscular Dystrophy: Antisense Oligomers and Exon Skipping
Current Molecular Pharmacology P-Selectin Antagonism in Inflammatory Disease
Current Pharmaceutical Design Mechanisms of Antihistamines and Mast Cell Stabilizers in Ocular Allergic Inflammation
Medicinal Chemistry Reviews - Online (Discontinued) Defensive and Offensive Cross-Reactive Antibodies Elicited by Pathogens: The Good, the Bad and the Ugly
Current Medicinal Chemistry