Abstract
Critically ill patients, particularly those under mechanical ventilation, require analgo-sedation to control noxious stimuli and enhance comfort. Despite their harmful side effects, such as respiratory depression, physical dependance and difficult arousal, opioids are effective in providing a good level of analgesia and comfort. Traditional opioids (morphine and fentanyl) have been shown effective in providing analgesia; however, the respiratory adverse effects and their pharmacokinetics, with an high risk of accumulation, limits their use, especially for a long-term sedation. In the last decade, new synthetic opioids with limited side effects and favourable pharmacokinetics profile, such as Sufentanil and Remifentanil, have been investigated to evaluate their efficacy in mitigating pain and enhancing comfort in critically ill patients.
Keywords: analgo-sedation, opioids, morphine, fentanyl, sufentanil, remifentanil
Current Drug Targets
Title: Analgesia in PACU: Intravenous Opioids
Volume: 6 Issue: 7
Author(s): G. Conti, R. Costa, A. Pellegrini, A. Craba and F. Cavaliere
Affiliation:
Keywords: analgo-sedation, opioids, morphine, fentanyl, sufentanil, remifentanil
Abstract: Critically ill patients, particularly those under mechanical ventilation, require analgo-sedation to control noxious stimuli and enhance comfort. Despite their harmful side effects, such as respiratory depression, physical dependance and difficult arousal, opioids are effective in providing a good level of analgesia and comfort. Traditional opioids (morphine and fentanyl) have been shown effective in providing analgesia; however, the respiratory adverse effects and their pharmacokinetics, with an high risk of accumulation, limits their use, especially for a long-term sedation. In the last decade, new synthetic opioids with limited side effects and favourable pharmacokinetics profile, such as Sufentanil and Remifentanil, have been investigated to evaluate their efficacy in mitigating pain and enhancing comfort in critically ill patients.
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Cite this article as:
Conti G., Costa R., Pellegrini A., Craba A. and Cavaliere F., Analgesia in PACU: Intravenous Opioids, Current Drug Targets 2005; 6 (7) . https://dx.doi.org/10.2174/138945005774574407
DOI https://dx.doi.org/10.2174/138945005774574407 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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