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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Cyclodextrin/Dendrimer Conjugates as DNA and Oligonucleotide Carriers

Author(s): Hidetoshi Arima, Keiichi Motoyama and Taishi Higashi

Volume 14 , Issue 4 , 2014

Page: [465 - 477] Pages: 13

DOI: 10.2174/1568026613666131219123610

Price: $65

Abstract

Recently, various cyclodextrin (CyD)-grafted polymers and supramolecules have been developed as gene and oligonucleotide carriers. We have demonstrated that among the various polyamidoamine starburstTM dendrimers (dendrimers) conjugates with CyDs (CDEs), the dendrimer (G2 or G3) conjugate with α-CyD showed high gene and oligonucleotide transfer activity with negligible cytotoxicity. In addition, to develop tissue- or cell-specific gene transfer carriers, we also prepared α-CDEs modified with functional molecules, such as mannose, fucose, galactose, lactose, polyethylene glycol (PEG) and folate-PEG. Moreover, polypseudorotaxane-appended α-CDEs were developed as sustained release systems for DNA and siRNA. Interestingly, glucronylglucosyl-β-CyD conjugates with dendrimer (G2) (GUG-β-CDE (G2)) showed high gene transfer activity compared to α-CDE (G2) and β-CDE (G2). In this review, we focus on the potential use of various CDEs as DNA and oligonucleotide transfer carriers.

Keywords: Cyclodextrin, polyamidoamine dendrimer, gene, oligonucleotide, sugars, folic acid, polypseudorotaxane.


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