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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Metabolism of Selegiline [(-)-Deprenyl)]

Author(s): H. Kalasz, K. Magyar, E. Szoke, E. Adeghate, A. Adem, M.Y. Hasan, S.M. Nurulain and K. Takes

Volume 21 , Issue 13 , 2014

Page: [1522 - 1530] Pages: 9

DOI: 10.2174/0929867321666131218094352

Price: $65

Abstract

Selegiline (1) [(-)-deprenyl] is used to treat patients with Parkinson’s disease. Nevertheless, in much higher doses it has beneficial effects in depression, and dementia of the aged patients. Selegiline (1) undergoes a complex metabolic pathway. Its major metabolites include (-)-desmethyldeprenyl (2), (-)-methamphetamine (3) and (-)-amphetamine (4), deprenyl-N-oxide (5) and formaldehyde (6) as a small metabolic fragment. In addition, more than 40 minor metabolites of selegiline (1) have also been either detected or proposed by investigators and researchers. This review analyses the pharmacological activity, generation pathway and the detection method of the major metabolites of selegiline (1).

Keywords: (-)-Amphetamine, (-)-desmethyldeprenyl, (-)-methamphetamine, deprenyl-N-oxide, formaldehyde, selegiline.


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