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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Recent Advances in Cinchona Alkaloid Catalysis for Enantioselective Carbon-Nitrogen Bond Formation Reactions

Author(s): Hiroaki Saito and Shinichi Miyairi

Volume 14 , Issue 2 , 2014

Page: [224 - 228] Pages: 5

DOI: 10.2174/1568026613666131213160228

Price: $65


Organocatalysis and cooperative catalysis are fast growing research areas. In these fields, cinchona alkaloids and their derivatives play a major role. The ready availability of both pseudo-enantiomeric pairs from natural sources makes them outstanding catalysts for reactions including oxidation, alkylation, cycloaddition, and carbene insertion. This short review focuses on recent achievements in the field of asymmetric carbon-nitrogen atom bond formation reactions using cinchona alkaloids and their derivatives.

Keywords: Cinchona alkaloids, enantioselective, N–H bond, organocatalysis, carbene.

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