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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Important Classes of Bioactive Alkaloids from Marine Ascidians: Structures, Isolation and Bioactivity

Author(s): Marialuisa Menna

Volume 14 , Issue 2 , 2014

Page: [207 - 223] Pages: 17

DOI: 10.2174/1568026613666131213155813

Price: $65

Abstract

An intensive research effort during the last 25 years has generated an impressive number of alkaloids isolated from marine ascidians, which remain unique among marine invertebrates in that they overwhelmingly produce this kind of metabolites. The present review is focused on some major groups of ascidians’ bioactive alkaloids, useful as lead structures in the search and development of new drugs or as biological probes for physiological investigation. They include the lamellarins, the ecteinascidins, bis-steroidal pyrazines and pyridoacridines. Their often extraordinary structures and significant biological activities are illustrated, reported syntheses are outlined, and structure/activity relationships are discussed where sufficient data are available to draw such conclusions. Recent discoveries concerning the current state of potential and /or development of some of them as new drugs as well as the current knowledge regarding their modes of action are also summarized.

Keywords: Marine natural products, marine invertebrates, ascidians, bioactive marine alkaloids, ecteinascidins, ritterazines, lamellarins, pyridoacridines.


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