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Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

A Facile Synthesis and Anticancer Activity Evaluation of Spiro Analogues of Benzothiazolylchromeno/pyrano Derivatives

Author(s): Anand Kumar Arya, Kulbhushan Rana and Mahendra Kumar

Volume 11 , Issue 5 , 2014

Page: [594 - 600] Pages: 7

DOI: 10.2174/1570180811666131210000903

Price: $65


The spiro analogues of benzothiazolylchromenopyranopyridine, benzothiazolyl- chromenoquinoline, benzothiazolylpyranoquinoline, benzothiazolylchromenopyridopyrimidine and benzothiazolylpyranopyridopyrimidine have been synthesized by an efficient domino reaction using sulfamic acid as catalyst in aqueous medium and screened for their cytotoxic activity against tumor cell lines, namely human cancer cell lines of colon (sw620), breast (MCF-7), cervix (HeLa) and heptatoma (HepG2) using a sulforhodamine B (SRB) assay. The synthesized compounds have shown promising cytotoxic activity against MCF-7 (breast cancer) & HeLa (cervical cancer) cancer cell lines.

Keywords: Multicomponent reactions, Spiroheterocycles, Cytotoxic activity, SRB assay, 2-aminobenzothiazole, Water.

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