Generic placeholder image

Current Nanoscience


ISSN (Print): 1573-4137
ISSN (Online): 1875-6786

The Role of Synovial Biomolecules Nano-Tribology in the Articulation Between Artificial Joint Materials

Author(s): Charng-Bin Yang, Huei-Ting Huang, Chia-Chun Chen, Yu-Hsun Lai, Chung-Hsiung Huang, Yung- Chang Lu and Hsu-Wei Fang

Volume 10, Issue 2, 2014

Page: [179 - 184] Pages: 6

DOI: 10.2174/1573413709666131128235726

Price: $65


Ultra-high molecular weight polyethylene (UHMWPE) wear debris induces osteolysis and leads to the loosening or failure of artificial joint. The lifetime of artificial joint is mainly determined by its tribological behaviors in synovial fluid. Various synovial fluid compositions such as albumin, globulin, hyaluronic acid (HA) and phospholipid might influence the tribological performance. Therefore, we investigated the nano-tribological behaviors of different biomolecules in synovial fluid for improving the lubrication of artificial joint. In this study, a biomimetic synovial fluid was used as baseline to examine the tribological effects of adding various biomolecules to synovial fluid. The results indicated that adding HA molecules to synovial fluid reduced the friction coefficient and increased the viscosity. Moreover, HA had the potential to decrease the friction caused by accumulative albumin and γ-globulin in synovial fluid. In summary, the findings demonstrated that HA was a critical synovial fluid molecule in dominating the lubricating properties of artificial joint. The efficient concentration of HA in synovial fluid could be adjusted to 4.5 mg/ml. The role of biomolecules in dominating the nanotribological process of artificial joint materials was investigated in this study. It was thought the nano-scaled interactions between the biomolecules may construct the major mechanisms.

Keywords: Artificial joint, biomimetic synovial fluid, friction, hyaluronic acid, lubrication, nanotribology, tribological behaviors.

Rights & Permissions Print Export Cite as
© 2023 Bentham Science Publishers | Privacy Policy